Pefabloc SC

Catalogue Number: 399-01
Size: 1 gm

Pefabloc SC is an irreversible proteinase inhibitor with broad specificity for serine proteinases.

Pefablocm SC is suitable for biopharmaceutical downstream purification because of its superior solubility, stability, inhibitory activity and low toxicity.

Chemical Formula: C8H10FNO2S⋅HCl

Identity: 4-(2-Aminoethyl)-benzenesulfonylfluoride hydrochloride (AEBSF)

Molecular Weight: 239.7

Solubility: 200 mg/ml in H₂O

IC50 values for a selection of enzymes determined at pH 7.0, 25oC after 15 minutes following incubation with Pefabloc SC

Enzyme	Enzyme Conc.	IC50 (mM)
Trypsin	0.2 ug/ml	0.081
Chymostrypsin	2.44 ug/ml	0.044
Thrombin	0.079 ug/ml	0.92
Factor Xa	0.12 ug/ml	24.0
Plasmin	4 CTA-U/ml	1.99
tPA	5.0 ug/ml	0.72
uPA	24.0 ug/ml	0.072
Glandular Kallikrein	3.5 ug/ml	2.86
Elastase	2.44 ug/ml	0.525
Subtilisin A	0.49 ug/ml	1.801
Factor XIIa	0.013 U/ml	0.256

References

Mintz GR. An irreversible serine protease inhibitor. Bio Pharm 1993; 6: 34-8.

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Pefabloc SC

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